Essential Formulas Incorporated (EFI) was established in 2000 as the sole U.S. distributor of world-renowned microbiologist Dr. Iichiroh Ohhira’s award-winning probiotic dietary supplements and skin care products. Always an innovator EFI introduced REG’ACTIV in 2015. Containing ME-3, a probiotic catalyst that produces the “Master’” Oxidant Glutothione inside the body’s own cells.