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Essential Formulas

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Vitamin & Mineral Safety 4th Edition (VMS4)


CRN Analysis Establishes Upper Limit for MK-7 Supplements

by Eric Munson | December 1, 2025

The Council for Responsible Nutrition (CRN) released its updated Vitamin K2 (menaquinone-7, MK-7) chapter as part of the Vitamin & Mineral Safety, 4th Edition (VMS4). CRN’s safety evaluation established a supplemental highest observed intake (HOI) level of 375 µg/day for adults. The new guidance is for manufacturers, regulators and health practitioners seeking evidence-based recommendations for ...

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