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Proprietary Nutritionals (Pharmachem Labs, Inc.): 2016 Science of Supplement Winter Issue

265 Harrison Ave.
Kearny, NJ 07032
Phone: (800) 526-0609 • Fax: (201) 246-8105
Email: info@celadrininfo.com
Website: www.celadrininfo.com


Today’s men and women in their 60s and 70s don’t just want to be able to walk and climb stairs, they want to be physically fit and play competitive sports. Americans are living longer and they also want to remain as active as possible with reduced joint discomfort. The Celadrin Tigerettes are an excellent example.

As the reigning Senior Olympic Women’s Basketball champs, the team has been competing (and winning) at the sport for 18 years. Along the way, they have accumulated five Senior Olympic gold medals and dozens of state and regional awards. This dynamic team, the only one of its kind that has a sponsor, will be once again playing in the national games in Birmingham, AL, in 2017.

The Celadrin Tigerettes know what it’s like to feel pain—but also to do what it takes to reduce the discomfort, including healthy diet, weight and aerobic training, and taking dietary supplements that include Celadrin—a supplement that is more relevant and attractive for active seniors than ever.

According to the Centers for Disease Control (CDC), 27 million Americans have osteoarthritis, and 42 percent of adults with physician-diagnosed OA (osteoarthritis) report activity limitations. In addition, approximately 454,000 knee replacements are performed due to OA. OA is often the result of simply “aging,” the wear and tear of joints due to repetitive motions and the movements of life (walking, sitting, stretching, reaching, etc.). But as those joints wear, they send pain signals, which compel individuals to move less, to truncate range of motion so as not to feel the spikes of pain.

Addressing Inflammation

Celadrin, a proprietary blend of esterified fatty acids, is one of the most effective natural ingredients that supports healthy inflammatory response to address the sensation of pain in knees, especially in the main joints—knees. In studies, adults have shown remarkable benefits of reduced pain and swelling, increased movement and reduction of inflammatory factors when using Celadrin. For example, results of a double-blind, multi-center, placebo-controlled trial (the most scientifically validated type) published in the prestigious Journal of Rheumatology found that Celadrin, when taken orally, improved parameters of aging joints, such as mobility and pain. In this study, 64 participants between the ages of 37 to 77 were given Celadrin capsules. They were evaluated at the beginning, at 30 days and at the end of the 68-day study. Compared to those in the placebo group, participants who consumed Celadrin had more flexibility, less aches and pain and were able to walk longer distances.1

In an earlier placebo-controlled study, 40 patients with knee OA applied either a Celadrin cream or placebo cream, twice daily for 30 days, and were evaluated for functional performance of their knees—such as knee range of motion, timed “up-and-go” from a chair, stair climbing, medial step-down test and the unilateral anterior reach. The results showed improved range of motion of the knees in the Celadrin group, with no improvement in the placebo group. For example, significant improvement was reported in the Celadrin group for the medial step-down test, unilateral anterior reach. The authors concluded that use of Celadrin as a cream is an effective tool “for improving knee ROM, ability to ascend/descend stairs, rise from sitting, walk and sit down and unilateral balance.”2

The esterified fatty acids in Celadrin have pronounced healthy inflammatory response effects, such as the inhibition of the endothelial cells and decreasing the pro-inflammatory effects of other fatty acids. The special fatty acids found in Celadrin have also been shown to reduce the production of the negative immune factor IL-6 and to control other immune factors responsible for inflammation. This alone could explain some effects of Celadrin, such as reduction of pain in joints affected by degradation. And certainly, these functions are very important in preventing further tissue and joint damage while promoting healing. It also works by inhibiting arachidonic acid, one of the main promoters of the inflammatory cascade of immune factors by inhibiting 5-lipoxygenase, another mediator of inflammation. It may also alter cellular membranes protecting them from the action of inflammatory cytokines or by reducing the secretion of inflammatory cytokines and CRP. Additionally, the molecules found in Celadrin may also play a role in lubrication of an affected joint. This action combined with anti-inflammatory effects, explain some of the significant improvements in mobility and function.


1 Robert Hesslink Jr, et al, “Cetylated Fatty Acids Improve Knee Function in Patients with Osteoarthritis.” J Rheumatol 2002;29:1708-12.

2 Kraemer, WJ, et al. “Effect of a Cetylated Fatty Acid Topical Cream on Functional Mobility and Quality of Life of Patients with Osteoarthritis” J Rheumatol 2004;31:767-74.